Mullany, P;
Allan, E;
Roberts, AP;
(2015)
Mobile genetic elements in Clostridium difficile and their role in genome function.
Res Microbiol
, 166
(4)
pp. 361-367.
10.1016/j.resmic.2014.12.005.
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Abstract
Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains to toxin producers. Mobile genetic elements have also been adapted by investigators to probe the biology of the organism and the various ways in which these have been used are reviewed.
| Type: | Article |
|---|---|
| Title: | Mobile genetic elements in Clostridium difficile and their role in genome function. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.resmic.2014.12.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.resmic.2014.12.005 |
| Language: | English |
| Additional information: | © 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Bacteriophage, Conjugative transposon, Horizontal gene transfer, PaLoc, Tn5397, Tn916 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1463406 |
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