Wild, EJ;
Boggio, R;
Langbehn, D;
Robertson, N;
Haider, S;
Miller, JR;
Zetterberg, H;
... Weiss, A; + view all
(2015)
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
J Clin Invest
10.1172/JCI80743.
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Abstract
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously.
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