Hamilton, N;
Diaz-de-Cerio, N;
Whitmore, D;
(2015)
Impaired light detection of the circadian clock in a zebrafish melanoma model.
Cell Cycle
, 14
(8)
1232 - 1241.
10.1080/15384101.2015.1014146.
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Abstract
The circadian clock controls the timing of the cell cycle in healthy tissues and clock disruption is known to increase tumourigenesis. Melanoma is one of the most rapidly increasing forms of cancer and the precise molecular circadian changes that occur in a melanoma tumor are unknown. Using a melanoma zebrafish model, we have explored the molecular changes that occur to the circadian clock within tumors. We have found disruptions in melanoma clock gene expression due to a major impairment to the light input pathway, with a parallel loss of light-dependent activation of DNA repair genes. Furthermore, the timing of mitosis in tumors is perturbed, as well as the regulation of certain key cell cycle regulators, such that cells divide arhythmically. The inability to co-ordinate DNA damage repair and cell division is likely to promote further tumourigenesis and accelerate melanoma development.
| Type: | Article |
|---|---|
| Title: | Impaired light detection of the circadian clock in a zebrafish melanoma model |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/15384101.2015.1014146 |
| Publisher version: | http://dx.doi.org/10.1080/15384101.2015.1014146 |
| Language: | English |
| Additional information: | © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC© Noémie Hamilton, Natalia Diaz-de-Cerio, and David Whitmore This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| Keywords: | cancer, cell cycle, circadian clock, light input, melanoma, zebrafish |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1466207 |
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