Revier, CJ; Reininghaus, U; Dutta, R; Fearon, P; Murray, RM; Doody, GA; Croudace, T; ... Jones, PB; + view all Revier, CJ; Reininghaus, U; Dutta, R; Fearon, P; Murray, RM; Doody, GA; Croudace, T; Dazzan, P; Heslin, M; Onyejiaka, A; Kravariti, E; Lappin, J; Lomas, B; Kirkbride, JB; Donoghue, K; Morgan, C; Jones, PB; - view fewer (2015) Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study. Journal of Nervous and Mental Disease , 203 (5) pp. 379-386. 10.1097/NMD.0000000000000295.

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Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

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