Houldcroft, CJ;
(2015)
Sequencing drug-resistant cytomegalovirus in paediatric patients: towards personalised medicine.
Future Virology
, 10
(7)
pp. 813-816.
10.2217/fvl.15.58.
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Abstract
Cytomegalovirus is an ubiquitous herpesvirus that causes silent-to-mild infections in healthy individuals, and potentially fatal infections in the immunocompromised, especially paediatric patients. CMV reactivation during periods of intense immune suppression is associated with significant economic costs and poor patient outcomes. With a limited range of drugs licensed to treat CMV reactivation, managing antiviral resistance is vital. In research settings, high-throughput sequencing is superseding PCR-based monitoring of resistance mutations, revealing a more complicated – and more informative – picture of emerging mutation profiles in clinical samples. In the next decade, it is foreseeable that CMV whole genome sequencing for management of antiviral drug resistance will become as important for personalised patient care as qPCR monitoring of virus loads is today.
| Type: | Article |
|---|---|
| Title: | Sequencing drug-resistant cytomegalovirus in paediatric patients: towards personalised medicine |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/fvl.15.58 |
| Publisher version: | http://dx.doi.org/10.2217/fvl.15.58 |
| Language: | English |
| Additional information: | Copyright © 2015 Future Medicine Ltd. |
| Keywords: | Herpesviruses, Next-generation sequencing, TORCH infection, Immune suppression, Immune deficiency, Evolution, antivirals |
| UCL classification: | UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1469276 |
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