Ólafsdóttir, HF; Barry, C; Saleem, AB; Hassabis, D; Spiers, HJ; (2015) Hippocampal place cells construct reward related sequences through unexplored space. eLife , 4 , Article e06063. 10.7554/eLife.06063.

Preview

Text Hippocampal place cells construct reward related sequences through unexplored space..pdf Available under License : See the attached licence file. Download (1MB)

Abstract

Dominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery of food to an unvisited portion of an environment leads to off-line pre-activation of place cells sequences corresponding to that space. Such 'preplay' was not observed for an unrewarded but otherwise similar portion of the environment. These results suggest that a hippocampal representation of a visible, yet unexplored environment can be formed if the environment is of motivational relevance to the animal. We hypothesise such goal-biased preplay may support preparation for future experiences in novel environments.

Download activity - last month

Export as CSVXMLJSON

Download activity - last 12 months

Export as CSVXMLJSON

Downloads by country - last 12 months

Export as CSVJSONXML

Archive Staff Only

View Item