Platé, M;
Lawson, PJ;
Hill, MR;
Marshall, RP;
Booth, HL;
Kumari, M;
Laurent, GJ;
... Chambers, RC; + view all
(2015)
Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.
[Letter].
Respirology
, 20
(8)
pp. 1285-1287.
10.1111/resp.12608.
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Abstract
Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene-environment interactions. Proteinase-activated receptor-1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case-control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52-0.88)).
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