Patel, S;
Roncaglia, P;
Lovering, RC;
(2015)
Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.
BMC Bioinformatics
, 16
, Article 186. 10.1186/s12859-015-0622-0.
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Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism..pdf Download (3MB) | Preview |
Abstract
People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is known to be associated with a combination of genetic and environmental factors. Neurexins and neuroligins play a key role in synaptogenesis and neurexin-neuroligin adhesion is one of several processes that have been implicated in autism spectrum disorders.
| Type: | Article |
|---|---|
| Title: | Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12859-015-0622-0 |
| Publisher version: | http://dx.doi.org/10.1186/s12859-015-0622-0 |
| Language: | English |
| Additional information: | © 2015 Patel et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Animals, Autistic Disorder, Cell Adhesion Molecules, Neuronal, Cell Physiological Phenomena, Gene Ontology, Genome, Genomics, High-Throughput Nucleotide Sequencing, Humans, Membrane Potentials, Mice, Models, Molecular, Nerve Tissue Proteins, Phenotype, Rats, Social Behavior, Synapses, Synaptic Potentials |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1472457 |
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