Bhosale, G;
Sharpe, JA;
Sundier, SY;
Duchen, MR;
(2015)
Calcium signaling as a mediator of cell energy demand and a trigger to cell death.
Annals of the New York Academy of Sciences
, 1350
(1)
pp. 107-116.
10.1111/nyas.12885.
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Abstract
Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.
| Type: | Article |
|---|---|
| Title: | Calcium signaling as a mediator of cell energy demand and a trigger to cell death |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/nyas.12885 |
| Publisher version: | http://dx.doi.org/10.1111/nyas.12885 |
| Language: | English |
| Additional information: | © 2015 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | MICU1, calcium signaling, cell death, ischemia/reperfusion injury, mitochondrial calcium uptake, mitochondrial permeability transition pore |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1472687 |
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