Baio, G; Dawid, AP; (2008) Probabilistic Sensitivity Analysis in Health Economics. (Research Report 292/08, Department of Statistical Science 292/08 ). University College London: London.

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Abstract

Health economic evaluations have recently built upon more advanced statistical decision-theoretic foundations and nowadays it is officially required that uncertainty about both parameters and observable variables be taken into account thoroughly, increasingly often by means of Bayesian methods. Among these, Probabilistic Sensitivity Analysis (PSA) has assumed a predominant role and Cost Effectiveness Acceptability Curves (CEACs) are established as the most important tool. The objective of this paper is to review the problem of health economic assessment from the standpoint of Bayesian statistical decision theory with particular attention to the philosophy underlying the procedures for sensitivity analysis. We advocate here the use of an integrated vision that is based on the value of information analysis, a procedure that is well grounded in the theory of decision under uncertainty, and criticise the indiscriminate use of other approaches to sensitivity analysis.

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