Hoh Kam, J;
Lynch, A;
Begum, R;
Cunea, A;
Jeffery, G;
(2015)
Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.
Experimental Eye Research
, 135
pp. 59-66.
10.1016/j.exer.2015.03.023.
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Abstract
Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without clinical resolution. Here, we show using aged mice that 2-Hydroxypropyl-β-cyclodextrin, a sugar molecule given as eye drops over 3 months results in significant reductions in Aβ by 65% and inflammation by 75% in the aged mouse retina. It also elevates retinal pigment epithelium specific protein 65 (RPE65), a key molecule in the visual cycle, in aged retina. These changes are accompanied by a significant improvement in retinal function measured physiologically. 2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model. β-cyclodextrin is economic, safe and may provide an efficient route to reducing the impact of retinal ageing.
| Type: | Article |
|---|---|
| Title: | Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.exer.2015.03.023 |
| Publisher version: | http://dx.doi.org/10.1016/j.exer.2015.03.023 |
| Language: | English |
| Additional information: | © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Cyclodextrin, Lipid, RPE65, Retinal ageing, Retinal amyloid beta, Retinal inflammation, Administration, Topical, Aging, Amyloid beta-Peptides, Analysis of Variance, Animals, Complement C3, Disease Models, Animal, Electroretinography, Inflammation, Membrane Lipids, Mice, Mice, Inbred C57BL, Retina, beta-Cyclodextrins, cis-trans-Isomerases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1473091 |
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