Mahalingam, S;
Xu, Z;
Edirisinghe, M;
(2015)
Antibacterial activity and biosensing of PVA-lysozyme microbubbles formed by pressurized gyration.
Langmuir
, 31
(36)
pp. 9771-9780.
10.1021/acs.langmuir.5b02005.
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Abstract
In this work, the biosensing and antibacterial capabilities of PVA-lysozyme microbubbles have been explored. Gas-filled PVA-lysozyme microbubbles with and without gold nanoparticles in the diameter range of 10 to 250 μm were produced using a single-step pressurized gyration process. Fluorescence microscopy showed the integration of gold nanoparticles on the shell of the microbubbles. Microbubbles prepared with gold nanoparticles showed greater optical extinction values than those without gold nanoparticles, and these values increased with the concentration of the gold nanoparticles. Both types of microbubbles showed antibacterial activity against Gram-negative Escherichia coli (E. coli), with the bubbles containing the gold nanoparticles performing better than the former. The conjugation of the microbubbles with alkaline phosphatase allowed the detection of pesticide paraoxon in aqueous solution, and this demonstrates the biosensing capabilities of these microbubbles.
| Type: | Article |
|---|---|
| Title: | Antibacterial activity and biosensing of PVA-lysozyme microbubbles formed by pressurized gyration |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.langmuir.5b02005 |
| Publisher version: | http://dx.doi.org/10.1021/acs.langmuir.5b02005 |
| Additional information: | © 2015 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1473151 |
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