Joerg, DJ;
Morelli, LG;
Soroldoni, D;
Oates, AC;
Juelicher, F;
(2015)
Continuum theory of gene expression waves during vertebrate segmentation.
New Journal of Physics
, 17
, Article 093042. 10.1088/1367-2630/17/9/093042.
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Abstract
The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebrate segmentation that captures the key principles governing the dynamic patterns of gene expression including the effects of shortening of the oscillating tissue.Weshow that our theory can quantitatively account for the key features of segmentation observed in zebrafish, in particular the shape of the wave patterns, the period of segmentation and the segment length as a function of time.
| Type: | Article |
|---|---|
| Title: | Continuum theory of gene expression waves during vertebrate segmentation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1367-2630/17/9/093042 |
| Publisher version: | http://dx.doi.org/10.1088/1367-2630/17/9/093042 |
| Language: | English |
| Additional information: | Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
| Keywords: | coupled oscillators, morphogenesis, pattern formation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1474472 |
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