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Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

Wijeratne, PA; Vavourakis, V; Hipwell, JH; Voutouri, C; Papageorgis, P; Stylianopoulos, T; Evans, A; (2016) Multiscale modelling of solid tumour growth: the effect of collagen micromechanics. Biomechanics and Modeling in Mechanobiology , 15 (5) pp. 1079-1090. 10.1007/s10237-015-0745-2. Green open access

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Abstract

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre-fibre and tumour-fibre interactions. We hypothesise that such a model, which provides a purely mechanical description of tumour-host interactions, can be used to explain experimental observations of the effect of collagen micromechanics on solid tumour growth. The model was specified to mouse tumour data, and numerical simulations were performed. The multiscale model produced lower stresses than an equivalent continuum-like approach, due to a more realistic remodelling of the collagen microstructure. Furthermore, solid tumour growth was found to cause a passive mechanical realignment of fibres at the tumour boundary from a random to a circumferential orientation. This is in accordance with experimental observations, thus demonstrating that such a response can be explained as purely mechanical. Finally, peritumoural fibre network anisotropy was found to produce anisotropic tumour morphology. The dependency of tumour morphology on the peritumoural microstructure was reduced by adding a load-bearing non-collagenous component to the fibre network constitutive equation.

Type: Article
Title: Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10237-015-0745-2
Publisher version: http://dx.doi.org/10.1007/s10237-015-0745-2
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Fibre remodelling, Finite element analysis, Microenvironment, Tumour mechanics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery-pp.ucl.ac.uk/id/eprint/1474710
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