Speyer, B;
Abramov, B;
Saab, W;
Doshi, A;
Sarna, U;
Harper, JC;
Serhal, P;
(2013)
Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds.
Journal of Obstetrics and Gynaecology
, 33
(7)
pp. 697-700.
10.3109/01443615.2013.810199.
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Abstract
The aim was to investigate the influence of various biological factors upon the outcome of intrauterine insemination (IUI). The total IUI history (856 cycles) of 352 couples was studied. Live-birth showed a strong negative correlation with female age but no correlation with male age. Antimullerian hormone (AMH) and antral follicle count (AFC) correlated negatively with female age, and follicle stimulating hormone (FSH) correlated positively. Significant thresholds were found for all three variables, and also for total motile count (TMC) in the prepared sperm. Calculating pregnancy losses per positive pregnancy showed a strong correlation with increasing female age. This was highly significant for biochemical losses but not for fetal heart miscarriages. Male age had no effect on rate of pregnancy loss. In conclusion, female age, FSH, AMH and TMC are good predictive factors for live-birth and therefore relate to essential in vivo steps in the reproductive process.
| Type: | Article |
|---|---|
| Title: | Factors influencing the outcome of intrauterine insemination (IUI): age, clinical variables and significant thresholds |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3109/01443615.2013.810199 |
| Publisher version: | http://dx.doi.org/10.3109/01443615.2013.810199 |
| Language: | English |
| Additional information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Obsterics and Gynaecology on 15 October 2013, available online: http://www.tandfonline.com/10.3109/01443615.2013.817976 |
| Keywords: | Antimüllerian hormone, female age, FSH, intrauterine insemination, pregnancy loss, total motile count |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1476297 |
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