Fan, Q;
Foster, P;
Verhoeven, VJM;
Wojciechowski, R;
Barathi, VA;
Hysi, PG;
Guggenheim, JA;
... Saw, SM; + view all
(2016)
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error.
Nature Communications
, 7
, Article 11008. 10.1038/ncomms11008.
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Abstract
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 x 10 5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
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