Gibbs, KL;
Greensmith, L;
Schiavo, G;
(2015)
Regulation of Axonal Transport by Protein Kinases.
Trends in Biochemical Sciences
, 40
(10)
pp. 597-610.
10.1016/j.tibs.2015.08.003.
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Abstract
The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic dynein, which carry their cargoes along microtubule tracks. Protein kinases regulate axonal transport through direct phosphorylation of motors, adapter proteins, and cargoes, and indirectly through modification of the microtubule network. The misregulation of axonal transport by protein kinases has been implicated in the pathogenesis of several nervous system disorders. Here, we review the role of protein kinases acting directly on axonal transport and discuss how their deregulation affects neuronal function, paving the way for the exploitation of these enzymes as novel drug targets.
| Type: | Article |
|---|---|
| Title: | Regulation of Axonal Transport by Protein Kinases |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tibs.2015.08.003 |
| Publisher version: | http://dx.doi.org/10.1016/j.tibs.2015.08.003 |
| Language: | English |
| Additional information: | Copyright © 2015 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, CULTURED HIPPOCAMPAL-NEURONS, GLYCOGEN-SYNTHASE KINASE-3, AMYLOID PRECURSOR PROTEIN, LEMUR TYROSINE KINASE-2, CYTOPLASMIC DYNEIN, RETROGRADE TRANSPORT, IN-VIVO, C-JUN, ANTEROGRADE TRANSPORT, TAU PHOSPHORYLATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1480353 |
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