Liu, C;
Hu, M;
Zeng, X;
Nair, SP;
Xu, J;
(2016)
Photodynamic inactivation of Candida albicans by hematoporphyrin monomethyl ether.
Future Microbiology
, 11
(3)
pp. 351-362.
10.2217/fmb.15.142.
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Abstract
AIM: To evaluate the capacity of hematoporphyrin monomethyl ether (HMME) in the presence of light to cause photodynamic inactivation (PDI) of Candida albicans. MATERIALS & METHODS: HMME photoactivity was evaluated against azole-susceptible and -resistant C. albicans. The mechanisms by which PDI of C. albicans occurred were also investigated. RESULTS: HMME-mediated PACT caused a dose-dependent inactivation of azole-susceptible and -resistant C. albicans. Incubation with 10 μM HMME and irradiation with 72 J cm(-2) light decreased the viability of C. albicans by 7 log10, induced damage of genomic DNA, led to loss of cellular proteins and damaged the cell wall, membrane and intracellular targets. CONCLUSION: Candida albicans can be effectively inactivated by HMME in the presence of light, and HMME-mediated PACT shows its potential as an antifungal treatment.
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