Leibovici, L;
Paul, M;
Garner, P;
Sinclair, DJ;
Afshari, A;
Pace, NL;
Cullum, N;
... Tovey, D; + view all
(2016)
Addressing resistance to antibiotics in systematic reviews of antibiotic interventions.
Journal of Antimicrobial Chemotherapy
, 71
(9)
pp. 2367-2369.
10.1093/jac/dkw135.
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Abstract
Antibiotics are among the most important interventions in healthcare. Resistance of bacteria to antibiotics threatens the effectiveness of treatment. Systematic reviews of antibiotic treatments often do not address resistance to antibiotics even when data are available in the original studies. This omission creates a skewed view, which emphasizes short-term efficacy and ignores the long-term consequences to the patient and other people. We offer a framework for addressing antibiotic resistance in systematic reviews. We suggest that the data on background resistance in the original trials should be reported and taken into account when interpreting results. Data on emergence of resistance (whether in the body reservoirs or in the bacteria causing infection) are important outcomes. Emergence of resistance should be taken into account when interpreting the evidence on antibiotic treatment in randomized controlled trials or systematic reviews.
| Type: | Article |
|---|---|
| Title: | Addressing resistance to antibiotics in systematic reviews of antibiotic interventions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jac/dkw135 |
| Publisher version: | http://dx.doi.org/10.1093/jac/dkw135 |
| Language: | English |
| Additional information: | Copyright © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The version of record [Leibovici, L; Paul, M; Garner, P; Sinclair, DJ; Afshari, A; Pace, NL; Cullum, N; (2016) Addressing resistance to antibiotics in systematic reviews of antibiotic interventions. Journal of Antimicrobial Chemotherapy 10.1093/jac/dkw135] is available online at doi: 10.1093/jac/dkw135 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1493161 |
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