Howorka, S;
(2016)
Nanotechnology: Changing of the guard.
Science
, 352
(6288)
pp. 890-891.
10.1126/science.aaf5154.
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Howorka Science 2016 final accepted versio.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Membrane proteins control access of ions and molecules to a cell's interior, shuttle cargo and information across the cell boundary, and determine the cell's shape. Engineering the function of these proteins is key to the development of vaccines, biofuels, biosensor elements, and research tools. However, the range of accessible architectures is limited, because protein engineering usually involves making relatively modest structural changes to existing protein structures; folding extensively altered polypeptides into defined structures is very challenging. Recent studies have shown that some membrane-protein functions can be mimicked with DNA nanostructures, which are easier to manipulate than their natural templates.
| Type: | Article |
|---|---|
| Title: | Nanotechnology: Changing of the guard |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.aaf5154 |
| Publisher version: | http://dx.doi.org/10.1126/science.aaf5154 |
| Language: | English |
| Additional information: | Copyright © 2016 American Association for the Advancement of Science. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Journal on 20 May 2016: Vol. 352, Issue 6288, pp. 890-891; DOI: 10.1126/science.aaf5154 and is available at http://dx.doi.org/10.1126/science.aaf5154 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1493484 |
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