Petzold, A;
Steenwijk, MD;
Eikelenboom, JM;
Wattjes, MP;
Uitdehaag, BMJ;
(2016)
Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study.
Multiple Sclerosis Journal
, 22
(9)
pp. 1154-1162.
10.1177/1352458516645206.
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Abstract
BACKGROUND: Body fluid and structural imaging biomarkers give information on neurodegeneration. The relationship over time is not known in multiple sclerosis. OBJECTIVE: To investigate the temporal relationship of elevated cerebrospinal fluid (CSF) neurofilament (Nf) protein levels, a biomarker for axonal loss, with magnetic resonance imaging (MRI) atrophy measures. METHODS: In patients with multiple sclerosis, CSF Nf heavy chain (NfH) phosphoform levels were quantified at baseline and dichotomised into ‘normal’ and ‘high’. Atrophy was assessed by MRI at baseline and 15-year follow-up using SIENAX and FreeSurfer software. RESULTS: High baseline CSF NfHSMI35 levels predicted pronounced atrophy at 15-year follow-up (odds ratio (OR): 36, p < 0.01), in the absence of baseline brain atrophy (OR: 28, p < 0.05), for the averaged MRI normalised brain volume (1.44 L vs 1.33 L, p < 0.05), normalised grey matter volume (0.77 L vs 0.69 L, p < 0.01) and putamen (12.7 mL vs 10.7 mL, p < 0.05). Region-specific calculations including the spinal cord showed that a power of >80% is reached with 14–50 patients. CONCLUSION: These data suggest that high CSF NfH levels are an early predictor of later brain and spinal cord atrophy using structural imaging biomarkers and can be investigated in reasonably sized patient cohorts.
| Type: | Article |
|---|---|
| Title: | Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1352458516645206 |
| Publisher version: | http://doi.org/10.1177/1352458516645206 |
| Language: | English |
| Additional information: | © The Author(s), 2016. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Neurodegeneration, multiple sclerosis, cerebrospinal fluid, CSF, biomarker, neurofilaments, TRANSSYNAPTIC AXONAL DEGENERATION, CEREBROSPINAL-FLUID ANALYSIS, STANDING MULTIPLE-SCLEROSIS, CENTRAL-NERVOUS-SYSTEM, WALLERIAN DEGENERATION, MACROPHAGE RESPONSES, OUTCOME MEASURES, OPTIC NEURITIS, VISUAL PATHWAY, DIAGNOSIS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1498486 |
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