Mbale, EW;
Moxon, CA;
Mukaka, M;
Chagomerana, M;
Glover, S;
Chisala, N;
Omar, S;
... Mallewa, M; + view all
(2016)
HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children.
Journal of Infection
, 73
(3)
pp. 189-199.
10.1016/j.jinf.2016.05.012.
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Abstract
OBJECTIVES: Study of the effect of HIV on disease progression in heterogeneous severe malaria syndromes with imprecise diagnostic criteria has led to varying results. Characteristic retinopathy refines cerebral malaria (CM) diagnosis, enabling more precise exploration of the hypothesis that HIV decreases the cytokine response in CM, leading to higher parasite density and a poor outcome. METHODS: We retrospectively reviewed data on clinical progression and laboratory parameters in 877 retinopathy-positive CM cases admitted 1996–2011 (14.4% HIV-infected) to a large hospital in Malawi. Admission plasma levels of TNF, interleukin-10, and soluble intercellular adhesion molecule (sICAM-1) were measured by ELISA in 135 retinopathy-positive CM cases. RESULTS: HIV-infected CM cases had lower median plasma levels of TNF (p = 0.008), interleukin-10 (p = 0.045) and sICAM-1 (p = 0.04) than HIV-uninfected cases. Although HIV-infected children were older and more likely to have co-morbidities, HIV-status did not significantly affect parasite density (p = 0.90) or outcome (24.8% infected, vs. 18.5% uninfected; p = 0.13). CONCLUSION: In this well-characterised CM cohort, HIV-coinfection was associated with marked blunting of the inflammatory response but did not affect parasite density or outcome. These data highlight the complex influence of HIV on severe malaria and bring into question systemic inflammation as a primary driver of pathogenesis in human CM.
| Type: | Article |
|---|---|
| Title: | HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jinf.2016.05.012 |
| Publisher version: | https://doi.org/10.1016/j.jinf.2016.05.012 |
| Language: | English |
| Additional information: | Copyright © 2016 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Cerebral malaria; HIV; Paediatric; TNF |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1505676 |
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