Thompson, AJ;
Ontaneda, D;
Fox, RJ;
Cohen, JA;
(2017)
Progressive multiple sclerosis: Prospects for disease therapy, repair, and restoration of function.
The Lancet
, 389
(10076)
pp. 1357-1366.
10.1016/S0140-6736(16)31320-4.
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Abstract
Multiple sclerosis is a major cause of neurological disability, which accrues predominantly during progressive forms of the disease. Although development of multifocal inflammatory lesions is the underlying pathological process in relapsing-remitting multiple sclerosis, the gradual accumulation of disability that characterises progressive multiple sclerosis seems to result more from diffuse immune mechanisms and neurodegeneration. As a result, the 14 anti-inflammatory drugs that have regulatory approval for treatment of relapsing-remitting multiple sclerosis have little or no efficacy in progressive multiple sclerosis without inflammatory lesion activity. Effective therapies for progressive multiple sclerosis that prevent worsening, reverse damage, and restore function are a major unmet need. In this Series paper we summarise the current status of therapy for progressive multiple sclerosis and outline prospects for the future.
| Type: | Article |
|---|---|
| Title: | Progressive multiple sclerosis: Prospects for disease therapy, repair, and restoration of function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S0140-6736(16)31320-4 |
| Publisher version: | http://doi.org/10.1016/S0140-6736(16)31320-4 |
| Language: | English |
| Additional information: | © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1507827 |
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