Telford, R;
Seaton, CC;
Clout, A;
Buanz, A;
Gaisford, S;
Williams, GR;
Prior, TJ;
... Scowen, IJ; + view all
(2016)
Stabilisation of metastable polymorphs: the case of paracetamol form III.
Chemical Communications
, 52
(81)
pp. 12028-12031.
10.1039/c6cc05006a.
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Abstract
The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.
| Type: | Article |
|---|---|
| Title: | Stabilisation of metastable polymorphs: the case of paracetamol form III |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6cc05006a |
| Publisher version: | http://dx.doi.org/10.1039/c6cc05006a |
| Language: | English |
| Additional information: | © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, Cambridge Structural Database, Crystal, Growth, Raman |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1508087 |
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