Warburton, PJ;
Amodeo, N;
Roberts, AP;
(2016)
Mosaic tetracycline resistance genes encoding ribosomal protection proteins.
Journal of Antimicrobial Chemotherapy
, 71
(12)
pp. 3333-3339.
10.1093/jac/dkw304.
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Abstract
First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.
| Type: | Article |
|---|---|
| Title: | Mosaic tetracycline resistance genes encoding ribosomal protection proteins |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jac/dkw304 |
| Publisher version: | http://dx.doi.org/10.1093/jac/dkw304 |
| Language: | English |
| Additional information: | © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Microbiology, Pharmacology & Pharmacy, MEGASPHAERA-ELSDENII STRAINS, MOLECULAR CHARACTERIZATION, ANTIBIOTIC USE, SWINE, NOMENCLATURE, DETERMINANT, HYBRID, ELEMENT, SAMPLES, TET(U) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1511945 |
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