Suomi, V;
Jaros, J;
Treeby, B;
Cleveland, R;
(2016)
Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the Kidney.
In:
The Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
(pp. pp. 5648-5651).
Institute of Electrical and Electronics Engineers (IEEE): Orlando, Florida, USA.
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Abstract
Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and soundspeed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0.1 dB. Focal point shifting due to refraction effects resulted in -1.3, 2.6 and 1.3 mm displacements in x-, y- and z-directions respectively. Furthermore, focal point splitting into several smaller subvolumes was observed. The total volume of the secondary focal points was approximately 46% of the largest primary focal point. This could potentially lead to undesired heating outside the target location and longer therapy times.
| Type: | Proceedings paper |
|---|---|
| Title: | Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the Kidney |
| Event: | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
| ISBN-13: | 978-1-4577-0220-4 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/EMBC.2016.7592008 |
| Publisher version: | http://dx.doi.org/10.1109/EMBC.2016.7592008 |
| Language: | English |
| Additional information: | Copyright © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1515774 |
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