Price, SJ;
(2016)
Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms.
Evolutionary Bioinformatics
, 11
(S2)
pp. 71-82.
10.4137/EBO.S33490.
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Abstract
Recent research on genome evolution of large DNA viruses has highlighted a number of incredibly dynamic processes that can facilitate rapid adaptation. The genomes of amphibian-like ranaviruses – double-stranded DNA viruses infecting amphibians, reptiles, and fish (family Iridoviridae) – were examined to assess variation in genome content and evolutionary processes. The viruses studied were closely related, but their genome content varied considerably, with 29 genes identified that were not present in all of the major clades. Twenty-one genes had evidence of recombination, while a virus isolated from a captive reptile appeared to be a mosaic of two divergent parents. Positive selection was also found to be acting on more than a quarter of Ranavirus genes and was found most frequently in the Spanish common midwife toad virus, which has had a severe impact on amphibian host communities. Efforts to resolve the root of this group by inclusion of an outgroup were inconclusive, but a set of core genes were identified, which recovered a well-supported species tree.
| Type: | Article |
|---|---|
| Title: | Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4137/EBO.S33490 |
| Publisher version: | http://dx.doi.org/10.4137/EBO.S33490 |
| Language: | English |
| Additional information: | © the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CCCC-BY 4.0 License. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Evolutionary Biology, Mathematical & Computational Biology, comparative genomics, pathogen, aquaculture, phylogenetics, COMPLETE SEQUENCE DETERMINATION, MAJOR CAPSID PROTEIN, FAMILY-IRIDOVIRIDAE, MULTIPLE ALIGNMENT, PHYLOGENETIC ANALYSIS, POPULATION GENOMICS, GROUPER IRIDOVIRUS, GENETIC ALGORITHM, MOLECULAR-BIOLOGY, GENUS RANAVIRUS, comparative genomics, pathogen, aquaculture, phylogenetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1515917 |
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