Wheeler, GM;
Sweeting, MJ;
Mander, AP;
(2016)
AplusB: A Web Application for Investigating A plus B Designs for Phase I Cancer Clinical Trials.
PLOS ONE
, 11
(7)
, Article e0159026. 10.1371/journal.pone.0159026.
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Abstract
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
| Type: | Article |
|---|---|
| Title: | AplusB: A Web Application for Investigating A plus B Designs for Phase I Cancer Clinical Trials |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0159026 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0159026 |
| Language: | English |
| Additional information: | Copyright: © 2016 Wheeler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CONTINUAL REASSESSMENT METHOD, ONCOLOGY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1516211 |
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