Gordon, E;
Rohrer, JD;
Fox, NC;
(2016)
Advances in neuroimaging in frontotemporal dementia.
Journal of Neurochemistry
, 138
(S1)
pp. 193-210.
10.1111/jnc.13656.
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Abstract
Frontotemporal dementia (FTD) is a clinically and neuroanatomically heterogeneous neurodegenerative disorder with multiple underlying genetic and pathological causes. Whilst initial neuroimaging studies highlighted the presence of frontal and temporal lobe atrophy or hypometabolism as the unifying feature in patients with FTD, more detailed studies have revealed diverse patterns across individuals, with variable frontal or temporal predominance, differing degrees of asymmetry, and the involvement of other cortical areas including the insula and cingulate, as well as subcortical structures such as the basal ganglia and thalamus. Recent advances in novel imaging modalities including diffusion tensor imaging, resting-state functional magnetic resonance imaging and molecular positron emission tomography imaging allow the possibility of investigating alterations in structural and functional connectivity and the visualisation of pathological protein deposition. This review will cover the major imaging modalities currently used in research and clinical practice, focusing on the key insights they have provided into FTD, including the onset and evolution of pathological changes and also importantly their utility as biomarkers for disease detection and staging, differential diagnosis and measurement of disease progression. Validating neuroimaging biomarkers that are able to accomplish these tasks will be crucial for the ultimate goal of powering upcoming clinical trials by correctly stratifying patient enrolment and providing sensitive markers for evaluating the effects and efficacy of disease-modifying therapies.
| Type: | Article |
|---|---|
| Title: | Advances in neuroimaging in frontotemporal dementia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jnc.13656 |
| Publisher version: | http://dx.doi.org/10.1111/jnc.13656 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Frontotemporal dementia, neuroimaging, AMYOTROPHIC-LATERAL-SCLEROSIS, NEUROFILAMENT LIGHT-CHAIN, PROGRESSIVE SUPRANUCLEAR PALSY, CEREBROSPINAL-FLUID BIOMARKERS, LOBAR DEGENERATION EPIDEMIOLOGY, ALZHEIMERS-DISEASE PATIENTS, MILD COGNITIVE IMPAIRMENT, C9ORF72 REPEAT EXPANSION, MULTIPLE-SYSTEM ATROPHY, BETA-PP-BETA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1516773 |
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