Ribeiro Ribeiro, AL;
da Costa, NM;
de Siqueira, AS;
Brasil da Silva, W;
da Silva Kataoka, MS;
Jaeger, RG;
de Melo Alves-Junior, S;
... de Jesus Viana Pinheiro, J; + view all
(2016)
Keratocystic odontogenic tumor overexpresses invadopodia-related proteins, suggesting invadopodia formation.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
, 122
(4)
pp. 500-508.
10.1016/j.oooo.2016.06.004.
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Ribeiro et al Keratocystic odontogenic tumor overexpresses invadopodia-related proteins SPLIT.pdf Download (991kB) | Preview |
Abstract
OBJECTIVE: Keratocystic odontogenic tumor (KOT) is an odontogenic neoplasm that shows aggressive clinical behavior and local invasiveness. Invadopodia are actin-rich cellular protrusions exhibiting proteolytic pericellular activity, thereby inducing focal invasion in neoplastic cells and increasing neoplasms aggressiveness. Thus, this study aimed to evaluate immunoexpression of invadopodia-related proteins, cortactin, MT1-MMP, Tks4, and Tks5, in KOT. STUDY DESIGN: Immunohistochemistry of 16 cases of KOT, eight cases of calcifying cystic odontogenic tumor (CCOT), and eight samples of the oral mucosa (OM) was carried out to assess the expression of the above described invadopodia-related proteins in the basal and suprabasal layer. RESULTS: KOT samples showed higher and significant immunoexpression of cortactin, MT1-MMP, TKs4, and TKs5 compared with the CCOT and OM samples. Significant expression of all these proteins was observed in the basal layer compared with the suprabasal layer in KOT. CONCLUSIONS: Overexpression of cortactin, MT1-MMP, TKs4, and TKs5 was observed in KOT compared with samples of CCOT and OM. These proteins were also overexpressed in the basal over the suprabasal layer of KOT samples. Taken together, these results suggest the participation of invadopodia-related proteins on the pathogenesis of this lesion.
| Type: | Article |
|---|---|
| Title: | Keratocystic odontogenic tumor overexpresses invadopodia-related proteins, suggesting invadopodia formation |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.oooo.2016.06.004 |
| Publisher version: | http://dx.doi.org/10.1016/j.oooo.2016.06.004 |
| Language: | English |
| Additional information: | Copyright © 2016 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Keratocystic odontogenic tumor; odontogenic tumors; invadopodia; cortactin; membrane type I matrix metalloproteinase (MT1-MMP); Tks4; Tks5 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1521093 |
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