Willis, MD;
Pickersgill, TP;
Robertson, NP;
Lee, RW;
Dick, AD;
Carreño, E;
(2017)
Alemtuzumab-induced remission of multiple sclerosis-associated uveitis.
International Ophthalmology
, 37
(5)
pp. 1229-1233.
10.1007/s10792-016-0370-9.
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Abstract
PURPOSE: The purpose of the study was to report a case of multiple sclerosis (MS)-associated uveitis refractory to conventional immunosuppressants, with subsequent remission following treatment with alemtuzumab. METHODS: Case report Patient was treated with intravenous alemtuzumab, a lymphocyte depleting anti-CD52 monoclonal antibody that has recently been approved for use in relapsing MS. RESULTS: A 17-year-old female presented with bilateral optic neuritis and subsequently bilateral intermediate uveitis and secondary macular oedema. She was diagnosed with active relapsing MS for which she received treatment with alemtuzumab. The intraocular inflammation previously refractory to conventional immunosuppressants responded to alemtuzumab, inducing remission. CONCLUSIONS: To our knowledge, this is the first such report of alemtuzumab treatment in MS-associated ocular inflammatory disease and may demonstrate a potential utility for this drug in related conditions.
| Type: | Article |
|---|---|
| Title: | Alemtuzumab-induced remission of multiple sclerosis-associated uveitis |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10792-016-0370-9 |
| Publisher version: | http://dx.doi.org/10.1007/s10792-016-0370-9 |
| Language: | English |
| Additional information: | The final publication is available at Springer via http://dx.doi.org/10.1007/s10792-016-0370-9 |
| Keywords: | Alemtuzumab, Intraocular inflammation, Multiple sclerosis, Uveitis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1522464 |
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