Azevedo, C;
Saiardi, A;
(2017)
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective.
Trends in Biochemical Sciences
, 42
(3)
pp. 219-231.
10.1016/j.tibs.2016.10.008.
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Abstract
Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis. Recent data suggest that metabolic and signaling interplay between PP-IPs, ATP, and inorganic polyphosphate (polyP) influences and is influenced by cellular phosphate homeostasis. Different studies have demonstrated that the SPX protein domain is a key component of proteins involved in phosphate metabolism. How PP-IPs control some aspects of phosphate homeostasis has become clearer with the recently acquired crystal structures of SPX domains. We review here recent studies on eukaryote phosphate homeostasis and provide insights into future research.
| Type: | Article |
|---|---|
| Title: | Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tibs.2016.10.008 |
| Publisher version: | http://dx.doi.org/10.1016/j.tibs.2016.10.008 |
| Language: | English |
| Additional information: | Copyright © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Keywords: | SPX domain, inorganic polyphosphate, inositol pyrophosphates, metabolism, phosphate, signaling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1530786 |
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