Melbourne, A;
Pratt, R;
Owen, D;
Sokloska, M;
Bainbridge, A;
Atkinson, D;
Kendall, G;
... Ourselin, S; + view all
(2016)
Placental Image Analysis using Coupled Diffusion-Weighted and Multi-Echo T2 MRI and a Multi-Compartment Model.
In:
Proceedings of PIPPI 2016.
MICCAI Workshop on Perinatal, Preterm and Paediatric Image analysis (PIPPI): Athens, Greece.
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Abstract
Current popular methods of ow and uid measurement are confounded by the interaction of relaxation and perfusion characteristics which are rarely simultaneously considered. To address this shortcoming we propose a new multi-compartment model for the tissue signal in MRI and apply this to placenta imaging data. Motivated by the different flow characteristics across the placenta, a three compartment model comprising fast and slowly circulating uid pools and a tissue pool is fitted to overlapping multi-echo T2 relaxometry and an intra-voxel incoherent motion diffusion acquisition with low b-values. The new model is supported by a modified image acquisition to enable successful model fitting, but this acquisition is clinically practical; we implemented the acquisition on a standard 1.5T clinical system with acquisition taking less than 20 minutes with 26 slices. This is particularly important for placenta image acquisition. We test this combined acquisition and model-fitting routine on simulated data and show parametric maps for a placenta dataset.
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