Idland, A-V;
Sala-Llonch, R;
Borza, T;
Watne, LO;
Wyller, TB;
Braekhus, A;
Zetterberg, H;
... Fjell, AM; + view all
(2017)
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults.
Neurobiology of Aging
, 49
pp. 138-144.
10.1016/j.neurobiolaging.2016.09.012.
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Abstract
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, β-amyloid 1–42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight participants had full data available. A subgroup of 36 participants with very low AD risk was also studied. NFL predicted hippocampal atrophy rate independently of age, β-amyloid 1–42, and P-tau. Including NFL, P-tau, and age in the same model, higher NFL and lower P-tau predicted higher hippocampal atrophy (R2 = 0.20, NFL: β = −0.34; p = 0.003; P-tau: β = 0.27; p = 0.009). The results were upheld in the participants with very low AD risk. NFL predicted neurodegeneration in older adults with very low AD probability. We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration.
| Type: | Article |
|---|---|
| Title: | CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neurobiolaging.2016.09.012 |
| Publisher version: | http://doi.org/10.1016/j.neurobiolaging.2016.09.01... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, Cerebrospinal Fluid, Magnetic Resonance Imaging, Normal Aging, Neurofilament Light, Hippocampal Atrophy Rate, Cerebrospinal-Fluid, Alzheimers-Disease, Neurodegenerative Diseases, Multiple-Sclerosis, Biological Markers, Rotterdam Scan, Brain Atrophy, Risk-Factors, Protein, Biomarkers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1538336 |
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