Thompson, AJ;
Kobelt, G;
Berg, J;
Gannedahl, M;
Eriksson, J;
(2017)
New insights into the burden and costs of multiple sclerosis in Europe.
Multiple Sclerosis Journal
, 23
(8)
pp. 1123-1136.
10.1177/1352458517694432.
Preview |
Text
Thompson_Kobelt et al_New Insights-burden-cost-MS-Europe_MSJ_2017_23-8_1123-1136.pdf - Published Version Download (1MB) | Preview |
Abstract
BACKGROUND: The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. OBJECTIVES: This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. METHODS: A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity). RESULTS: The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing–remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. CONCLUSION: Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.
| Type: | Article |
|---|---|
| Title: | New insights into the burden and costs of multiple sclerosis in Europe |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1352458517694432 |
| Publisher version: | https://doi.org/10.1177/1352458517694432 |
| Language: | English |
| Additional information: | © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Multiple sclerosis, burden of illness, fatigue, cognition, costs, HRQoL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1538634 |
Archive Staff Only
 |
View Item |
