Mumith, A;
Coathup, M;
Chimutengwende-Gordon, M;
Aston, W;
Briggs, T;
Blunn, G;
(2017)
Augmenting the osseointegration of endoprostheses using laser-sintered porous collars: an in vivo study.
Bone and Joint Journal
, 99-B
(2)
pp. 276-282.
10.1302/0301-620X.99B2.BJJ-2016-0584.R1.
Preview |
Text
Chimutengwende-Gordon_augmenting the osseointegration_.pdf - Accepted Version Download (394kB) | Preview |
Abstract
AIMS: Massive endoprostheses rely on extra-cortical bone bridging (ECBB) to enhance fixation. The aim of this study was to investigate the role of selective laser sintered (SLS) porous collars in augmenting the osseointegration of these prostheses. MATERIALS AND METHODS: The two novel designs of porous SLS collars, one with small pores (Ø700 μm, SP) and one with large pores (Ø1500 μm, LP), were compared in an ovine tibial diaphyseal model. Osseointegration of these collars was compared with that of a clinically used solid, grooved design (G). At six months post-operatively, the ovine tibias were retrieved and underwent radiological and histological analysis. RESULTS: Porous collars provided a significantly greater surface (p < 0.001) for the ingrowth of bone than the standard grooved design. Significantly greater extracortical pedicle formation was seen radiologically around the grooved design (length p = 0.002, thickness p < 0.001, surface area p = 0.002) than around the porous collars. However, the ingrowth of bone occurred from the transection site into the porous structure of both types of collar. A fivefold increase in integration was seen with the SP and a threefold increase in the LP design when compared with G (p < 0.001). CONCLUSION: SLS porous collars allow the direct ingrowth of more bone and are better than current designs which rely on surface ongrowth and ECBB. Cite this article: Bone Joint J 2017;99-B:276-82.
Type: | Article |
---|---|
Title: | Augmenting the osseointegration of endoprostheses using laser-sintered porous collars: an in vivo study |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1302/0301-620X.99B2.BJJ-2016-0584.R1 |
Publisher version: | http://doi.org/10.1302/0301-620X.99B2.BJJ-2016-058... |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Endoprosthesis, In vivo, Osteointegration, Porous metal, Selective laser sintering, Animals, Coated Materials, Biocompatible, Durapatite, Female, Lasers, Osseointegration, Porosity, Prostheses and Implants, Prosthesis Design, Prosthesis Failure, Sheep, Tibia, Titanium |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1540765 |
Archive Staff Only
![]() |
View Item |