Chavez-Gutierrez, L;
De Strooper, B;
(2016)
Probing gamma-secretase-substrate interactions at the single amino acid residue level.
EMBO Journal
, 35
(15)
pp. 1597-1599.
10.15252/embj.201694978.
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Abstract
Intramembrane proteolysis by γ‐secretases plays major roles in disease pathology and cellular signalling, yet the dynamics of these enzyme complexes and how they recognize substrates remains poorly understood. New work in The EMBO Journal utilizes photo‐affinity cross‐linking to map APP interactions to different γ‐secretase subunits, suggesting a succession of recruitment and engagement steps that lead up to substrate cleavage.
| Type: | Article |
|---|---|
| Title: | Probing gamma-secretase-substrate interactions at the single amino acid residue level |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/embj.201694978 |
| Publisher version: | http://doi.org/10.15252/embj.201694978 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1541549 |
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