Katsnelson, A;
De Strooper, B;
Zoghbi, HY;
(2016)
Neurodegeneration: From cellular concepts to clinical applications.
Science Translational Medicine
, 8
(364)
, Article 364ps18. 10.1126/scitranslmed.aal2074.
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Abstract
Developing therapies for neurodegenerative diseases will require new scientific approaches that take into account the detrimental effects of altered protein and RNA homeostasis on brain cells, the vulnerabilities of various organelles in certain diseases and aging neurons, and the complex multicellular interactions of the nervous system.
| Type: | Article |
|---|---|
| Title: | Neurodegeneration: From cellular concepts to clinical applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/scitranslmed.aal2074 |
| Publisher version: | http://dx.doi.org/10.1126/scitranslmed.aal2074 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimers-disease, lysosomal biogenesis, pink1, mutations, toxicity, tauopathies, autophagy, proteins, domains, neurons |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1542126 |
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