Baheerathan, A;
Brownlee, WJ;
Rugg-Gunn, F;
Chard, DT;
Trip, SA;
(2017)
Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide.
Multiple Sclerosis and Related Disorders
, 13
pp. 73-74.
10.1016/j.msard.2017.02.009.
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Abstract
Paroxysmal tonic spasms [PTS] are common in patients with neuromyelitis optica spectrum disorder (NMOSD).1 2 In patients with demyelinating disease, PTS can significantly reduce the quality of life, limit activities of daily living and the rehabilitative process following an acute relapse 3. As in patients with multiple sclerosis (MS), paroxysmal tonic spasms in NMOSD usually respond well to treatment with carbamazepine.2 However, the optimal treatment in patients where carbamazepine is contraindicated or poorly tolerated is unclear. We describe a patient with NMOSD with severe paroxysmal tonic spasms who did not tolerate carbamazepine but was successfully treated with lacosamide (Vimpat).
| Type: | Article |
|---|---|
| Title: | Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.msard.2017.02.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.msard.2017.02.009 |
| Language: | English |
| Additional information: | © 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher. |
| Keywords: | NMOSD; Paroxysomal tonic spasms; Pharmacotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1542326 |
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