Vasalaki, M;
Fabian, ID;
Reddy, MA;
Cohen, VM;
Sagoo, MS;
(2017)
Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma.
British Medical Bulletin
, 121
(1)
pp. 107-119.
10.1093/bmb/ldw053.
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Abstract
BACKGROUND: Retinoblastoma, uveal and conjunctival melanomas are important malignancies within the remit of ocular oncology. Outlined are the diagnostic features and management principles, as well as advancements in the field and current challenges. SOURCES OF DATA: Original papers, reviews and guidelines. AREAS OF AGREEMENT: Most eyes with retinoblastoma (International Intraocular Retinoblastoma Classification (IIRC) Group A-D) are salvaged, whereas advanced cases (Group E) remain a challenge. Despite a high rate of local tumour control in uveal melanoma, metastatic spread commonly occurs. Conjunctival melanoma is treated by complete resection, but high rates of local recurrence occur, with the possibility of systemic relapse and death. AREAS OF CONTROVERSY: Use of the IIRC in retinoblastoma, and systemic screening in melanomas. GROWING POINTS: Utilization of novel treatment modalities in retinoblastoma and an increasing understanding of the genetic basis of melanomas. AREAS TIMELY FOR DEVELOPING RESEARCH: Improvements in chemotherapy delivery in retinoblastoma and prognostic tests in melanomas.
| Type: | Article |
|---|---|
| Title: | Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/bmb/ldw053 |
| Publisher version: | http://dx.doi.org/10.1093/bmb/ldw053 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Choroidal melanoma, conjunctival melanoma, eye cancer, eye tumour, melanoma, retinoblastoma, uveal melanoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1542730 |
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