Harvala, H;
Frampton, D;
Grant, P;
Raffle, J;
Ferns, RB;
Kozlakidis, Z;
Kellam, P;
... ICONIC Consortium; + view all
Harvala, H;
Frampton, D;
Grant, P;
Raffle, J;
Ferns, RB;
Kozlakidis, Z;
Kellam, P;
Pillay, D;
Hayward, A;
Nastouli, E;
ICONIC Consortium;
- view fewer
(2017)
Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.
Eurosurveillance
, 22
(8)
10.2807/1560-7917.ES.2017.22.8.30466.
Abstract
We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.
| Type: |
Article
|
| Title: |
Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017. |
| Location: |
Sweden |
| Open access status: |
An open access version is available from UCL Discovery |
| DOI: |
10.2807/1560-7917.ES.2017.22.8.30466 |
| Publisher version: |
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.8.3... |
| Language: |
English |
| Additional information: |
This article is copyright of the authors, 2017. This is an open-access article distributed under the terms of
the Creative Commons Attribution (CC BY 4.0) Licence. You
may share and adapt the material, but must give appropriate
credit to the source, provide a link to the licence, and indicate if changes were made. |
| Keywords: |
Influenza, molecular, next generation sequencing, outbreak |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources |
| URI: |
https://discovery-pp.ucl.ac.uk/id/eprint/1544877 |
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