Wells, JCK;
Johnstone, RA;
(2017)
Modeling Developmental Plasticity in Human Growth: Buffering the Past or Predicting the Future?
In: Jasienska, G and Sherry, DS and Holmes, DJ, (eds.)
The Arc of Life: Evolution and Health Across the Life Course.
(pp. 21-39).
Springer: New York, NY, USA.
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Abstract
Substantial variation in adult body size between human populations is widely assumed in part to represent adaptation to local ecological conditions. Developmental plasticity contributes to such variability; however, there is debate regarding how this early-life process can produce adaptation when environments change within the life span. We developed a simple mathematical simulation model, testing how human fetuses could tailor their growth to ecological conditions without being oversensitive and hence prone to extremes of growth. Data on Indian rainfall (1871–2004) were used as an index of ecological conditions. The simulation model allowed the comparison of different strategies for processing these time-series data regarding (a) the toleration of short-term ecological variability and (b) the prediction of conditions in adulthood. We showed that ecological information processing is favored in environments prone to long-term ecological trends. Once this strategy is adopted, resistance to short-term ecological perturbations can be achieved either by lengthening the duration of developmental plasticity or by accumulating multigenerational influences. A multigenerational strategy successfully dampens the transmission of the effects of ecological shocks to future generations, but it does not predict or enable offspring to respond to longer-term conditions. However, this strategy does allow fetal growth to be tailored to the likely supply of nutrition from the mother in the period after birth, during when extrinsic mortality risk is high. Our model has implications for public health policies aimed at addressing chronic malnutrition.
| Type: | Book chapter |
|---|---|
| Title: | Modeling Developmental Plasticity in Human Growth: Buffering the Past or Predicting the Future? |
| ISBN-13: | 9781493940387 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-1-4939-4038-7_3 |
| Publisher version: | https://doi.org/10.1007/978-1-4939-4038-7_3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Developmental plasticity, Growth, Adaptation, Human ecology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1544991 |
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