Male, V;
(2017)
Liver-Resident NK Cells: The Human Factor.
Trends in Immunology
, 38
(5)
pp. 307-309.
10.1016/j.it.2017.02.008.
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Abstract
Mouse liver contains two natural killer (NK) cell populations, one of which recirculates while the other is tissue resident. Following this discovery, several groups have sought to identify liver-resident NK (lrNK) cells in humans. Here, I present an overview of recent advances in the field. NK cells represent only a small fraction of circulating lymphocytes, but account for up to 50% of the lymphocytes in the liver. Bulk liver NK cells have long been known to differ from their circulating counterparts, but only over the past 5 years has it become appreciated that the liver in fact contains two NK cell subsets: conventional NK cells (cNK), which circulate freely, and lrNK.
| Type: | Article |
|---|---|
| Title: | Liver-Resident NK Cells: The Human Factor |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.it.2017.02.008 |
| Publisher version: | http://dx.doi.org/10.1016/j.it.2017.02.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1546795 |
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