Jain, H; Mulay, S; Mullany, P; (2016) Persistence of endodontic infection and Enterococcus faecalis: Role of horizontal gene transfer. Gene Reports , 5 pp. 112-116. 10.1016/j.genrep.2016.09.010.

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Abstract

The endodontic literature states that a diversity of microorganisms is implicated in cause of root canal infection. There may be a possibility that the actual existence of a specific species is not as imperative as the presence of specific virulent strains of that organism. There are genetic modifications in the cell that furnish an organism with greater pathogenicity. Primary and persistent endodontic infections have difference in their micro-flora. Primary infections usually comprises of mostly anaerobic microbiota whereas multidrug resistant Enterococcus faecalis has been linked to persistent endodontic disease. Horizontal gene transfer is a mechanism that leads to a varied number of traits including acquired antibiotic resistance. Horizontal gene transfer takes place by three processes transduction, conjugation and transformation. The present review expatiates on the mechanism of horizontal gene transfer of acquired antibiotic resistance in E. faecalis.

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