Aghaizu, ND; Kruczek, K; Gonzalez-Cordero, A; Ali, RR; Pearson, RA; (2017) Chapter 8 - Pluripotent stem cells and their utility in treating photoreceptor degenerations. Progress in Brain Research , 231 pp. 191-223. 10.1016/bs.pbr.2017.01.001.

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Abstract

Age-related macular degeneration and inherited retinal degenerations represent the leading causes of blindness in industrialized countries. Despite different initiating causes, they share a common final pathophysiology, the loss of the light sensitive photoreceptors. Replacement by transplantation may offer a potential treatment strategy for both patient populations. The last decade has seen remarkable progress in our ability to generate retinal cell types, including photoreceptors, from a variety of murine and human pluripotent stem cell sources. Driven in large part by the requirement for renewable cell sources, stem cells have emerged not only as a promising source of replacement photoreceptors but also to provide in vitro systems with which to study retinal development and disease processes and to test therapeutic agents.

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