Neto, JP; Lopes, G; Frazao, J; Nogueira, J; Lacerda, P; Baiao, P; Aarts, A; ... Kampff, AR; + view all Neto, JP; Lopes, G; Frazao, J; Nogueira, J; Lacerda, P; Baiao, P; Aarts, A; Andrei, A; Musa, S; Fortunato, E; Barquinha, P; Kampff, AR; - view fewer (2016) Validating silicon polytrodes with paired juxtacellular recordings: method and dataset. Journal of Neurophysiology , 116 (2) pp. 892-903. 10.1152/jn.00103.2016.

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Abstract

Cross-validating new methods for recording neural activity is necessary to accurately interpret and compare the signals they measure. Here we describe a procedure for precisely aligning two probes for in vivo “paired-recordings” such that the spiking activity of a single neuron is monitored with both a dense extracellular silicon polytrode and a juxtacellular micropipette. Our new method allows for efficient, reliable, and automated guidance of both probes to the same neural structure with micrometer resolution. We also describe a new dataset of paired-recordings, which is available online. We propose that our novel targeting system, and ever expanding cross-validation dataset, will be vital to the development of new algorithms for automatically detecting/sorting single-units, characterizing new electrode materials/designs, and resolving nagging questions regarding the origin and nature of extracellular neural signals.

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