Khan, M;
Boyce, A;
Prieto-Merino, D;
Svensson, Å;
Wedgeworth, E;
Flohr, C;
(2017)
The Role of Topical Timolol in the Treatment of Infantile Hemangiomas: A Systematic Review and Meta-analysis.
Acta Dermato-Venereologica
, 97
(10)
pp. 1167-1171.
10.2340/00015555-2681.
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Abstract
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not be reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07-15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.
| Type: | Article |
|---|---|
| Title: | The Role of Topical Timolol in the Treatment of Infantile Hemangiomas: A Systematic Review and Meta-analysis |
| Location: | Sweden |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2340/00015555-2681 |
| Publisher version: | http://doi.org/10.2340/00015555-2681 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1554322 |
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