de Winde, CM;
Elfrink, S;
van Spriel, AB;
(2017)
Novel Insights into Membrane Targeting of B Cell Lymphoma.
Trends in Cancer
, 3
(6)
pp. 442-453.
10.1016/j.trecan.2017.04.006.
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Abstract
Standard therapy of patients with B cell non-Hodgkin lymphoma (B-NHL) predominantly consists of chemotherapy combined with anti-CD20 (e.g., rituximab) immunotherapy. However, relapse of aggressive B-NHL occurs frequently, and this may coincide with therapy resistance. This demonstrates the urgent need for exploring new lymphoma-targeted therapies. We review here recent insights in the pathophysiology of B-NHL and discuss CD20 and three alternative membrane targets (B cell receptor, immune checkpoints PD-1/PD-L1, tetraspanin CD37) that are currently in the spotlight for B-NHL treatment. Furthermore, we present a novel concept in which the plasma membrane organization of the lymphoma B cell determines the efficacy of membrane-targeted therapies, and this has consequences for treatment application and clinical outcome in patients with B cell lymphoma.
| Type: | Article |
|---|---|
| Title: | Novel Insights into Membrane Targeting of B Cell Lymphoma |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.trecan.2017.04.006 |
| Publisher version: | http://doi.org/10.1016/j.trecan.2017.04.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Non-Hodgkin lymphoma; B cell; immunotherapy; membrane target; membrane organization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1558078 |
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