Wong, LH;
Čopič, A;
Levine, TP;
(2017)
Advances on the Transfer of Lipids by Lipid Transfer Proteins.
[Review].
Trends in Biochemical Sciences
, 42
(7)
pp. 516-530.
10.1016/j.tibs.2017.05.001.
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Abstract
Transfer of lipid across the cytoplasm is an essential process for intracellular lipid traffic. Lipid transfer proteins (LTPs) are defined by highly controlled in vitro experiments. The functional relevance of these is supported by evidence for the same reactions inside cells. Major advances in the LTP field have come from structural bioinformatics identifying new LTPs, and from the development of countercurrent models for LTPs. However, the ultimate aim is to unite in vitro and in vivo data, and this is where much progress remains to be made. Even where in vitro and in vivo experiments align, rates of transfer tend not to match. Here we set out some of the advances that might test how LTPs work.
| Type: | Article |
|---|---|
| Title: | Advances on the Transfer of Lipids by Lipid Transfer Proteins |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tibs.2017.05.001 |
| Publisher version: | http://doi.org/10.1016/j.tibs.2017.05.001 |
| Language: | English |
| Additional information: | Copyright © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | lipid exchange, nonvesicular traffic, oxysterol binding protein-related proteins, tubular lipid binding proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1559702 |
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