Hagens, MH;
Killestein, J;
Yaqub, MM;
van Dongen, GA;
Lammertsma, AA;
Barkhof, F;
van Berckel, BN;
(2017)
Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study.
Multiple Sclerosis
10.1177/1352458517704507.
(In press).
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Abstract
Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration. The exact mechanisms leading to this rapid effect have not yet been clarified. The aim of this positron emission tomography study was to assess central nervous system penetration as a possible explanation, using zirconium-89-labelled rituximab. No evidence was found for cerebral penetration of [(89)Zr]rituximab.
| Type: | Article |
|---|---|
| Title: | Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1352458517704507 |
| Publisher version: | http://doi.org/10.1177/1352458517704507 |
| Language: | English |
| Additional information: | © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). |
| Keywords: | B-lymphocytes, Multiple sclerosis, magnetic resonance imaging, monoclonal antibodies, positron emission tomography, rituximab |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1563684 |
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